GLP-1 Drugs Like Ozempic Cut Depression and Anxiety Risk by Up to 44% in Landmark Study
A Lancet Psychiatry study of nearly 100,000 people over 13 years found GLP-1 medications reduce depression by 44%, anxiety by 38%, and substance use disorders by 47%. Researchers at Karolinska Institutet and collaborators suggest both lifestyle improvements and direct neurobiological mechanisms drive the mental health benefits — expanding the significance of these drugs far beyond weight management.